In a study done by Pharmatech among three groups of male subjects engaged in a weight training program, the two groups that used Belizean Man Vine extract gained lb and lb, respectively, more muscle mass than the placebo group over an eight-week period. The benefits reported, which were universal to all test subjects, are increased muscle mass, improved recovery times and increased strength. What is of particular interest is that group that gained more lb of muscle did so on a diet that consisted of 50% of the calories and protein than that of the group that gained lb, clearly demonstrating the anti-proteolytic action of the extract. It is also likely that the phenylethanoid glycosides can both increase recovery and enhance nitric oxide production (from histamine inhibition) may be contributory factors to the acquired muscle gains.
Once more, an early study done on S-4 provided proof of full muscle regeneration in volunteers with with degenerative disorders without the use of exercise and the minimum dosage of 3mg/kg/day. Changes can be seen anywhere from 1-2 weeks. This was the very first study classified S-4 as CLINICALLY SIGNIFICANT by improving skeletal muscle strength, lean body mass, and a reduction in body fat [Chen et al., 2005; Gao et al., 2005; Kearbey et al., 2007]. Unfortunately, there are always some side effects that arise when using Because S-4 is a ligand by definition, the side effects will never be permanent even at supraphysiological dosages and can be easily avoided through proper dosing.
It has some mild side effects associated with it as well. Side effects occur when you take it for a very long period of time and in more quantity. Major drawback of Anavar is that it is too costly, although available in black market but one cannot be so sure of the authenticity of it bought from there. As it is DHT and due to this hair loss and acne can occur. But hair loss only in men who have got this hair loss disease genetically transmitted. There could be high blood pressure and high cholesterol levels but only for those who are not living a healthy life style and these diseases are not transmitted genetically to the users as well. Due to the non aromatizing nature of Anavar it has taken side effects of water retention and Gynecomastia out of the equation.